Super important information for those looking to lose weight and restore muscle function!

Laura Burton NP-C, CFMP

21 East Acton

Wood River IL, 62095

(618) 219-0273

FAX-(618) 323-3833

If you are like tens of thousands of people right now looking to get their weight off and start building back muscle, than this information is for you! We at Full Circle Function have heard our patients loud and clear and are here to help them lose weight and help keep it off! Not using restrictive fad diets but by assessing the root cause of the weight gain and giving the body what it needs to burn fat and lose weight. Our bodies need certain nutrients to support our hormones that tell our bodies to burn fat for fuel instead of storing it. We, along with Innovation compounding pharmacy have developed weight loss protocols to help our patient meet their weight loss goals. This is especially good for athletes who are working out and either not seeing results or just want to ensure they are rebuilding muscles after their workouts! Here is some information on one of the injections available at FCF.

Glutamine/Ornithine HCl/Arginine HCl/Lysine HCl (GOAL)

Glutamine

• Fuel Source for Stressed Muscles

• Reduce Risk of Muscle Loss

• Aids in Recovery of Muscles

• Repair of Gut Tissues

• Preferred Source of Energy for the Brain

• Immune System Booster

• Aids in pH Balance

Glutamine is a conditionally essential amino acid being elevated to essential during periods of disease and muscle wasting in physical trauma. It is typically used for gut health, as gut cells use glutamine as preferred source of fuel over glucose. Doing approximately one hour of exercise can cause a 40 percent reduction of glutamine in the body. It can also cause suppressed immune function. This has a negative impact on resistance training and may lead to overtraining syndrome.

The amount of glutamine acquired by the normal diet does not provide adequate coverage for your muscles during times of intense exercise or stress. Cellular levels of glutamine post-workout have been shown to drop by 50 percent and plasma levels decreasing up to 30 percent. This muscle-wasting state is a gateway for the body to use the muscle for energy rather than carbohydrates. By supplementing with glutamine, the muscles become replenished and allow for a boost in strength and repair.

A study found that glutamine supplementation makes it possible to recover quickly from intense weight training sessions because it improves muscle hydration. This can help the muscle recovery process and reduces recovery time for wounds and burns. Glutamine also helps cleanse the body of high amounts of ammonia. Its buffering actions and ability to convert excess ammonia into other amino acids, amino sugars, and urea, supports healthy detoxification

One of L-glutamine’s main roles in the body is to support detoxification by cleansing the body from high levels of ammonia. It acts as a buffer and converts excess ammonia into other amino acids, amino sugars, and urea. L-glutamine also burns fat and builds lean muscle mass by helping suppress insulin levels and stabilize blood glucose. This enables the body to use up less muscle mass to maintain blood sugar and insulin sensitivity in the cells. In fact, six weeks of supplementation with 30 grams per day of glutamine powder markedly improved some cardiovascular risk factors, as well as body composition, in patients with type 2 diabetes. For this reason, L-glutamine benefits diabetics and those with sugar and carb cravings as well.1-6

Ornithine

• Supports Athletic Performance

• Strength and Power Support

• Anxiety Management

• Liver Support

• Supports Skin Repair

Ornithine is a nonprotein amino acid which eliminates excess nitrogen from the body via the urea cycle. It can be synthesized in the body so is not considered “essential”. L-Ornithine is thought to be important for conditions that are characterized by an excess level of ammonia, and this is mainly focused on either hepatic encephalopathy (clinical liver condition) or prolonged cardiovascular exercise Early research suggests that taking ornithine by mouth might reduce fatigue and improve measures of athletic performance such as speed, strength, and power in some people. While there are only two studies assessing exercise; the one that was better suited to assess the influence of ammonia (using prolonged exercise rather than acute exercise) did find an anti-fatigue effect.

Ornithine can cross the blood-brain barrier, converted to glutamine, and then converted to GABA which may support the studies surrounding its ability to reduce anxiety in animal trials. Animal studies show that ornithine may support healthy wound recovery due to its role in collagen production.7-9

L-Arginine

• Supports growth hormone

• Converts to nitric oxide

• Decreases muscle fatigue

• Promotes weight loss through insulin regulation

• Improves endothelial function

• Influences macronutrient metabolism

• Supports muscle metabolism, recovery, tendon healing

Arginine is an amino acid which is converted in the body into a chemical called nitric oxide. Nitric oxide causes blood vessels to open wider and improve blood flow. This is thought to have a significant effect on muscle metabolism and recovery and tendon healing. Arginine helps promote weight loss by stimulating the release insulin and other substances in the body. When combined with exercise, arginine has a stronger effect on the production of growth hormone to increase the body’s protein mass and build muscle.

Nitric oxide functions as a regulator of healthy blood pressure; a killer of bacteria and tumor cells; a messenger molecule to the brain involved in memory and thought process; a regulator of inflammation and the immune system; and many other important processes in the body.

Studies show that arginine has been shown to increase exercise performance. L-arginine has several important metabolic and biological effects, which include improving vascular function, being a substrate in the synthesis of creatine, and the ability to stimulate insulin, glucagon, catecholamines, and GH secretion, leading to anabolic and anti-catabolic effects on skeletal muscle. L-arginine decreases muscle fatigue during exercise by reducing exercise-induced accumulation of lactate and ammonia, which allows the muscle to perform for longer periods. In addition, recovery time is significantly decreased after exercise and training.

Increasing systemic levels of L-arginine has been demonstrated to significantly improve endothelial function in individuals with essential hypertension, compromised flow-mediated dilation, arterial stiffness, chronic heart failure, impaired glucose tolerance (MetS) and type 2 diabetes – all of which are common concomitant medical conditions associated with Erectile Dysfunction (ED).

Studies have shown that L-arginine influences macronutrient metabolism.10-16

Lysine

• Improves heart health

• Mood support

• Lowers cholesterol

• Calcium absorption

• Reduces risk of type-2 diabetes complications

• Increases insulin secretion

• Boosts athletic performance

• Increases collagen production

• Supports production of antibodies, enzymes, and hormones

Lysine is an essential amino acid that must be obtain from the diet or supplementation. It is a building block of protein which rose to popularity when it was found to help alleviate cold sores or HSV.

A key component in various physiological processes, deficiencies in lysine can lead to fatigue, agitation, reproductive disorder, nausea, anemia, loss of appetite, or stunted growth. Cooking at high temperatures can destroy the lysine in foods. Vegetarians are also found to be at risk from lysine deficiency. Grass fed products such as beef, chicken, turkey, organic pork and eggs, spirulina algae, and fenugreek seed can provide amounts of lysine in the diet.

Scientists have also found evidence that it increases the effectiveness of L-arginine in promoting human growth hormone (HGH) release. Suminski and colleagues found that HGH levels were greater when weightlifters ingested arginine and lysine without exercise. Lysine insures the adequate absorption of calcium, helps form collagen (which makes up bone cartilage & connective tissues) and aids in the production of antibodies, hormones and enzymes. L-Lysine helps maintain nitrogen levels, build muscle protein and speed muscle recovery when kept in adequate amounts in the body, due to its help in the conversion of fatty acids into energy.17-20

Recommendations: We generally recommend starting with 3 bottles or 2-3 injections a week for 3 months to see results although each person will vary

Disclaimer: Results vary from person to person depending on multiple factors. We cannot guarantee that this treatment will produce weight loss especially if not performed as an adjunct to balanced nutrition and exercise.

Call the office today at 618-219-0273 for more information or to sign up for a weight loss consultation!

REFERENCES

1.https://digitalcommons.lsu.edudocs/available/etd-06162005-142747/unrestricted/Piattoly_thesis.pdf

2. Bowtell JL, Gelly K. et al. Effect of oral glutamine on whole body carbohydrate storage during recovery from exhaustive exercise. Jour App Phys. Volume 86:6(1770-1777). June 1999

3. Wilmore DW. The Effect of Glutamine Supplementation in Patients Following Elective Surgery and Accidental Injury. The Journal of Nutrition, Volume 131, Issue 9, 1 September 2001, Pages 2543S–2549S

4. Shen J. Sibson NR., Cline G., et al. 15N-NMR spectroscopy studies of ammonia transport and glutamine synthesis in the hyperammonemic rat brain. Dev Neurosci. 1998;20(4-5):434-43.

5. Mansour A., Mohajeri-Tehrani MR., et al. Effect of glutamine supplementation on cardiovascular risk factors in patients with type 2 diabetes. Nutrition. 2015 Jan;31(1):119-26. doi: 10.1016/j.nut.2014.05.014. Epub 2014 Jun 23.

6. Greenfield JR., Farooqi IS., et al. Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects. Am J Clin Nutr. 2009 Jan;89(1):106-113. doi: 10.3945/ajcn.2008.26362. Epub 2008 Dec 3.

7. Demura S, et al. The effect of L-ornithine hydrochloride ingestion on performance during incremental exhaustive ergometer bicycle exercise and ammonia metabolism during and after exercise. Eur J Clin Nutr. (2010)

8. Coudray-Lucas C, et al. Ornithine alpha-ketoglutarate improves wound healing in severe burn patients: a prospective randomized double-blind trial versus isonitrogenous controls. Crit Care Med. (2000)

9. Sugino T, et al. L-ornithine supplementation attenuates physical fatigue in healthy volunteers by modulating lipid and amino acid metabolism. Nutr Res. (2008)

10. Murrell, G.A., Szabo, C., Hannafin, J.A., et al., Modulation of tendon healing by nitric oxide, Inflamm. Res., 46, 19-27, 1997.

11. Lin, J.H., Wang, M.X. Wei, A.Q., et al., Temporal expression of nitric oxide synthase isoforms in healing Achilles tendon, J. Orthop. Res., 19, 136- 142, 2001.

12. Lin, J.H., Wang, M.X. Wei, A.Q., et al., The cell specific temporal expression of nitric oxide synthase isoforms during Achilles tendon healing, Inflamm. Res., 50, 515-522, 2001.

13. Beaumier, L., Castillo, L., Yu., Y.M., Ajami, A.M., and Young, V.R., Arginine: New and exciting developments for an “old” amino acid, Biochem. Environ. Sci. 9(2-3), 296-315, 1996. 14. McConell, G.K., Huynh, N.N., Lee-Young, R.S., Canny, B.J., and Wadley, G.D., L-arginine infusion increases glucose clearance during prolonged exercise in humans, Am. J. Physiol. Endocrinol. Metab., 290(1), E60-E66, 2006.

15. Schaefer, A., Piquard, F., Geny, B., Doutreleau, S., Lampert, E., Mettauer, B., and Lonsdorfer, J., L-arginine reduces exercise-induced increase on plasma lactate and ammonia, Int. J. Sports Med., 23(6) 403-407, 2002

16. Meneguallo, M.O., Mendonca, J.R., Lancha, A.H., Jr., and Costa Rosa, L.F., Effect of arginine, ornithine, and citrulline supplementation upon performance and metabolism of trained rats, Cell. Biochem. Funct. 21(1), 85-91, 2003.

17. Isidori A., Monaco AL., Cappa M. A study of growth hormone release in man after oral administration of amino acids. Current Medical Research